Inhibitions of HMGB1 and TLR4 alleviate DINP-induced asthma in mice
نویسندگان
چکیده
منابع مشابه
Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis
Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMGB1), a potent inflammatory cytokine, and its respective receptor toll-like receptor-4 (TLR-4) in ...
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From the Departments of Medical Information, Respiratory Diseases, and Radiology, Montpellier University Hospital, Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, Montpellier University Hospital, Montpellier, France; APARD: Association pour l’Assistance et la R ehabilitation a Domicile, Montpellier, France; and the Department of Respiratory Diseases APHM, INSERM Laborat...
متن کاملHMGB1 translocation and release mediate cigarette smoke–induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway
We performed studies to determine the role of high-mobility group box 1 (HMGB1) in cigarette smoke (CS)-induced pulmonary inflammation. After mice were exposed to five cigarettes four times a day for 3 d, toll-like receptor 4 (TLR4) expression and TLR4-mediated signaling were significantly up-regulated, and HMGB1 had translocated from the nucleus to the cytoplasm in lung epithelial cells and th...
متن کاملImmunotherapy of Chenopodium Album Induced Asthma by Intranasal Administration of CpG Oligodeoxynucleotides in BALB/c Mice
Background: There are many therapeutic methods for allergic conditions. CpG oli-gonucleotides play a critical role in immunity via the augmentation of Th1 and suppres-sion of Th2 responses. Objective: In the present study we aimed to estimate the effec-tiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen...
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Following the publication of the article, the authors noted that there were certain errors in Fig. 5. In particular, the published Fig. 5A-a contains an image of H&E-stained micrographs from wild-type mice after the administration of a low dose of rhHMGB1, and not after the administration of a high dose of rhHMGB1, as should be shown. In addition, the data in the published graph of Fig. 5C-a is...
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ژورنال
عنوان ژورنال: Toxicology Research
سال: 2019
ISSN: 2045-4538
DOI: 10.1039/c9tx00048h